ENDOTHELIAL CELL-TO-CELL JUNCTIONS

被引:387
作者
DEJANA, E [1 ]
CORADA, M [1 ]
LAMPUGNANI, MG [1 ]
机构
[1] IST RIC FARMACOL MARIO NEGRI, VASC BIOL LAB, MILAN, ITALY
关键词
ENDOTHELIUM; PERMEABILITY; LEUKOCYTE DIAPEDESIS;
D O I
10.1096/fasebj.9.10.7615160
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The endothelium forms the main barrier to the passage of macromolecules and circulating cells from blood to tissues, Endothelial permeability is in large part regulated by intercellular junctions, These are complex structures formed by transmembrane adhesive molecules linked to a network of cytoplasmic/cytoskeletal proteins. At least four different types of endothelial junctions have been described: tight junctions, gap junctions, adherence junctions and syndesmos. These organelles have some features and components in common with epithelial cells but there are also some that are specific for the endothelium, The mechanisms that regulate the opening and closing of endothelial junctions are still obscure, It is conceivable that inflammatory agents increase permeabilty by binding to specific: receptors generating intracellular signals, which in turn cause cytoskeletal reorganization and opening of interendothelial cell gaps. Endothelial junctions also control leukocyte extravasation, Once leukocytes have adhered to the endothelium, a coordinated opening of interendothelial cell junctions occurs, The mechanism by which this takes place is unknow, but it might present characteristics similar to that triggered by soluble mediators.
引用
收藏
页码:910 / 918
页数:9
相关论文
共 57 条
  • [1] The structure and regulation of tight junctions
    Anderson, James Melvin
    Balda, Maria S.
    Fanning, Alan S.
    [J]. CURRENT OPINION IN CELL BIOLOGY, 1993, 5 (05) : 772 - 778
  • [2] SPATIAL AND TEMPORAL RELATIONSHIPS BETWEEN CADHERINS AND PECAM-1 IN CELL-CELL JUNCTIONS OF HUMAN ENDOTHELIAL-CELLS
    AYALON, O
    SABANAI, H
    LAMPUGNANI, MG
    DEJANA, E
    GEIGER, B
    [J]. JOURNAL OF CELL BIOLOGY, 1994, 126 (01) : 247 - 258
  • [3] MODULATION OF CA-2+-DEPENDENT INTERCELLULAR-ADHESION IN BOVINE AORTIC AND HUMAN UMBILICAL VEIN ENDOTHELIAL-CELLS BY HEPARIN-BINDING GROWTH-FACTORS
    BAVISOTTO, LM
    SCHWARTZ, SM
    HEIMARK, RL
    [J]. JOURNAL OF CELLULAR PHYSIOLOGY, 1990, 143 (01) : 39 - 51
  • [4] BERMAN ME, 1995, J IMMUNOL, V154, P299
  • [5] Beyer E C, 1993, Int Rev Cytol, V137C, P1
  • [6] BREVIARIO F, 1995, IN PRESS ATHER THROM
  • [7] CARLOS TM, 1994, BLOOD, V84, P2068
  • [8] CAVEDA L, 1994, ENDOTHELIUM, V2, P1
  • [9] CONFORTI G, 1992, BLOOD, V80, P437
  • [10] TUMOR VASCULAR-PERMEABILITY FACTOR STIMULATES ENDOTHELIAL-CELL GROWTH AND ANGIOGENESIS
    CONNOLLY, DT
    HEUVELMAN, DM
    NELSON, R
    OLANDER, JV
    EPPLEY, BL
    DELFINO, JJ
    SIEGEL, NR
    LEIMGRUBER, RM
    FEDER, J
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 1989, 84 (05) : 1470 - 1478