COMPUTER-ASSISTED MAPPING OF INFARCTED AND VIABLE REGIONS OF GROSS CARDIAC SECTIONS FOLLOWING EXPERIMENTAL MYOCARDIAL-INFARCTION

被引：1

作者：

DAMM, CJ ^{[1
]}

BIGGER, JT ^{[1
]}

URSELL, PC ^{[1
]}

STEINBERG, JS ^{[1
]}

SMITH, R ^{[1
]}

LENNON, PF ^{[1
]}

COOK, JR ^{[1
]}

机构：

[1] COLUMBIA UNIV,DEPT PATHOL,NEW YORK,NY 10027

来源：

COMPUTERS AND BIOMEDICAL RESEARCH | 1995年 / 28卷 / 03期

关键词：

D O I：

10.1006/cbmr.1995.1015

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

We have developed a computer-assisted method that creates digital maps of the viable and infarcted regions of tetrazolium-stained gross cardiac sections. Here we describe and test the method, using a canine occlusion-reperfusion infarction model. Quantitative image analysis showed that the method accurately recorded differences between infarcted and viable regions at a spatial resolution of 5-20 pixels per mm(2). Microscopic analysis of tissue samples taken from the sections showed that the maps were accurate. In 15 of 15 cases the histology of the samples matched that predicted by the maps. A comparison of infarct area measurements derived from the maps showed that the method was reproducible. The average intraoperator standard deviation was +/-8% of a slice's infarcted area and the average interoperator standard deviation was +/-20%. We conclude that the method creates accurate, detailed, and reproducible maps of the infarcted and viable regions of tetrazolium-stained cardiac sections. (C) 1995 Academic Press, Inc.

引用

页码：221 / 238

页数：18

共 30 条

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