CHEMICAL-STABILITY OF NEW UREA AND NITROSOUREA DERIVATIVES OF DIAMINO ACIDS

被引：2

作者：

DULUDE, H ^{[1
]}

SALVADOR, R ^{[1
]}

GALLANT, G ^{[1
]}

机构：

[1] UNIV MONTREAL,FAC PHARM,MED CHEM LAB,MONTREAL H3C 3J7,PQ,CANADA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 22期

关键词：

D O I：

10.1016/S0960-894X(01)80699-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Stability in neutral aqueous solutions of a series of nitrosourea derivatives of diamino acids was determined. Structure-activity relationships show that N-3-bisubstitution increased the stability of these compounds. Moreover, in N-3-monosubstituted and N-3-bisubstituted compounds, stability is : N-1-Methyl > N-1-Allyl > N-1-3-Chloroethyl > N-1-Propargyl.

引用

页码：2697 / 2700

页数：4

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