PRESYNAPTIC LOCALIZATION OF OMEGA-CONOTOXIN-SENSITIVE CALCIUM CHANNELS AT THE FROG NEUROMUSCULAR-JUNCTION

被引：44

作者：

TARELLI, FT

PASSAFARO, M

CLEMENTI, F

SHER, E

机构：

[1] CNR,CTR CYTOPHARMACOL,I-20133 MILAN,ITALY

[2] SCI INST S RAFFAELE,MILAN,ITALY

[3] UNIV MILAN,INST HUMAN ANAT,I-20122 MILAN,ITALY

来源：

BRAIN RESEARCH | 1991年 / 547卷 / 02期

关键词：

NEUROMUSCULAR JUNCTION; VOLTAGE-OPERATED CALCIUM CHANNEL; NEUROTRANSMITTER RELEASE; ACTIVE ZONE;

D O I：

10.1016/0006-8993(91)90981-Z

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

By the use of anti-omega-CTx antibodies in indirect immunofluorescence we demonstrated the presence of omega-CTx binding sites in the presynaptic compartment of frog nerve-muscle preparations. The images we obtained indicate that omega-CTx-sensitive channels are clustered at discrete sites corresponding in distribution to active zones.

引用

页码：331 / 334

页数：4

共 23 条

[1]

AUGUSTINE GJ, 1989, SECRETION ITS CONTRO, P203

[2] CLASSES OF CALCIUM CHANNELS IN VERTEBRATE CELLS [J].

BEAN, BP .

ANNUAL REVIEW OF PHYSIOLOGY, 1989, 51 :367-384

[3] PROPERTIES OF ISOLATED ADULT RAT MUSCLE-FIBERS MAINTAINED IN TISSUE-CULTURE [J].

BEKOFF, A ;

BETZ, W .

JOURNAL OF PHYSIOLOGY-LONDON, 1977, 271 (02) :537-&

[4] CA CURRENTS IN HUMAN NEUROBLASTOMA IMR32 CELLS - KINETICS, PERMEABILITY AND PHARMACOLOGY [J].

CARBONE, E ;

SHER, E ;

CLEMENTI, F .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1990, 416 (1-2) :170-179

[5]

COUTEAUX R, 1970, Comptes Rendus Hebdomadaires des Seances de l'Academie des Sciences Serie D Sciences Naturelles, V271, P2346

[6] ULTRASTRUCTURE OF ACTIVE-ZONE IN FROG NEUROMUSCULAR JUNCTION [J].

DREYER, F ;

PEPER, K ;

AKERT, K ;

SANDRI, C ;

MOOR, H .

BRAIN RESEARCH, 1973, 62 (02) :373-380

[7] PASSIVE TRANSFER OF LAMBERT-EATON MYASTHENIC SYNDROME WITH IGG FROM MAN TO MOUSE DEPLETES THE PRESYNAPTIC MEMBRANE ACTIVE ZONES [J].

FUKUNAGA, H ;

ENGEL, AG ;

LANG, B ;

NEWSOMDAVIS, J ;

VINCENT, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1983, 80 (24) :7636-7640

[8] PAUCITY AND DISORGANIZATION OF PRE-SYNAPTIC MEMBRANE ACTIVE ZONES IN THE LAMBERT-EATON MYASTHENIC SYNDROME [J].

FUKUNAGA, H ;

ENGEL, AG ;

OSAME, M ;

LAMBERT, EH .

MUSCLE & NERVE, 1982, 5 (09) :686-697

[9] FUNCTIONAL CHANGES IN FROG NEUROMUSCULAR-JUNCTIONS STUDIED WITH FREEZE-FRACTURE [J].

HEUSER, JE ;

REESE, TS ;

LANDIS, DMD .

JOURNAL OF NEUROCYTOLOGY, 1974, 3 (01) :109-131

[10] STRUCTURAL-CHANGES AFTER TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR-JUNCTION [J].

HEUSER, JE ;

REESE, TS .

JOURNAL OF CELL BIOLOGY, 1981, 88 (03) :564-580

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