AUTOANTIBODIES TO GBM AND NEUTROPHIL CYTOPLASM IN RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS

被引：241

作者：

JAYNE, DRW

MARSHALL, PD

JONES, SJ

LOCKWOOD, CM

机构：

[1] Off. of the Regius Prof. of Physic, Clinical Medical School, Addenbrookes Hospital

[2] Off. of the Regius Prof. of Physic, Clinical Medical School, Addenbrooke's Hospital, Cambridge CB2 2QQ, Hills Road

来源：

KIDNEY INTERNATIONAL | 1990年 / 37卷 / 03期

基金：

英国惠康基金;

关键词：

D O I：

10.1038/ki.1990.72

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The incidence of autoantibodies to glomerular basement membrane (AGBMA) and neutrophil cytoplasmic antigens (ANCA) in the initial sera of 889 consecutive patients with a suspected diagnosis of rapidly progressive glomerulonephritis, was determined by prospective study. Forty-seven (5%) were positive for AGBMA alone, 246 (28%) were positive for ANCA alone, 576 (65%) had neither autoantibodies while 20 (2%) had both. Clinical and pathological data collected from patients with both autoantibodies suggested the coexistence of anti-glomerular basement membrane disease and systemic vasculitis. Together, assays for AGBMA and ANCA are important in the diagnosis and management of rapidly progressive glomerulonephritis and may help its further classification.

引用

页码：965 / 970

页数：6

共 17 条

[1]

BOWMAN C, 1985, J CLIN LAB IMMUNOL, V17, P197

[2]

BROWN CB, 1974, LANCET, V2, P1166

[3] RAPIDLY PROGRESSIVE GLOMERULONEPHRITIS - CLASSIFICATION, PATHOGENETIC MECHANISMS, AND THERAPY [J].