EFFECT OF THE ACUTE SUBLINGUAL ADMINISTRATION OF KETANSERIN IN HYPERTENSIVE PATIENTS

被引：1

作者：

ALIBERTI, G

DERASMO, E

ODDO, CM

VECCI, E

机构：

[1] II Clinica Medica, University of Rome 'La Sapienza', Rome

来源：

CARDIOVASCULAR DRUGS AND THERAPY | 1991年 / 5卷 / 04期

关键词：

HYPERTENSION; KETANSERIN; SUBLINGUAL ADMINISTRATION;

D O I：

10.1007/BF03029743

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The purpose of this study has been to compare the acute antihypertensive effect of a dose of 20 mg of ketanserin in 18 patients after sublingual administration and in 19 after oral administration. In three patients ketanserin and ketanserin-ol plasma levels were measured after both sublingual and oral administration. The results showed a more rapid, considerable antihypertensive effect after sublingual administration. In addition, the high plasma levels of ketanserin-ol, the metabolite produced by hepatic reduction of ketanserin, reached after sublingual administration, rather than transmucosal absorption, indicate that the clinical effect observed is due to more rapid dissolution of the tablet formulation and liberation of the active drug.

引用

页码：697 / 699

页数：3

共 8 条

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