STUDIES ON SOME CRYSTALLINE FORMS OF IBUPROFEN

被引：29

作者：

LABHASETWAR, V ^{[1
]}

DESHMUKH, SV ^{[1
]}

DORLE, AK ^{[1
]}

机构：

[1] NAGPUR UNIV,DEPT PHARMACEUT SCI,NAGPUR 440010,MAHARASHTRA,INDIA

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1993年 / 19卷 / 06期

关键词：

D O I：

10.3109/03639049309062971

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Different crystal forms of ibuprofen were prepared and characterized by IR spectra, melting point, morphological structure, dissolution studies, and stability. Different forms were found to demonstrate variable physicochemical properties and dissolution rates, These ranged in physical appearance from prisms to needles and plates. The dissolution t70 ranged from 48 minutes to > 480 minutes. The stability study indicated that most of the crystal forms were stable at room temperature, and also at 60-degrees-C over one month.

引用

页码：631 / 641

页数：11

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