INUTERO TRANSPLANTATION OF FETAL LIVER STEM-CELLS INTO HUMAN FETUSES

被引：21

作者：

TOURAINE, JL

机构：

[1] Department of Transplantation and Clinical Immunology, Pav. P, Hôpital Edouard Herriot

来源：

HUMAN REPRODUCTION | 1992年 / 7卷 / 01期

关键词：

FETAL LIVER TRANSPLANTATION; INUTERO TRANSPLANTATION; STEM CELLS; SEVERE COMBINED IMMUNODEFICIENCY DISEASE; THALASSEMIA;

D O I：

10.1093/oxfordjournals.humrep.a137554

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Three human fetuses were treated by transplantation of human fetal liver stem cells. Two of them had severe immunodeficiency disease and the third had thalassaemia major. All three in-utero transplants were followed by engraftment. No adverse effect was seen. The three patients have now been born: the first is very healthy thanks to the reconstitution of cell-mediated immunity associated with this transplant, and he lives normally at home; the other two, who were treated more recently, have not yet shown a complete effect. The feasibility and efficacy of this procedure, used for the first time in humans, has therefore been demonstrated: during early fetal development, foreign cells engraft readily and may result in significant improvement of a large variety of inherited diseases.

引用

页码：44 / 48

页数：5

共 16 条

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