REDUCED SENSITIVITY OF TUBERCULOSIS SERODIAGNOSIS IN PATIENTS WITH AIDS IN UGANDA

被引：25

作者：

DANIEL, TM

SIPPOLA, AA

OKWERA, A

KABENGERA, S

HATANGA, E

AISU, T

NYOLE, S

BYEKWASO, F

VJECHA, M

FERGUSON, LE

KATAAHA, P

MUGERWA, RD

机构：

[1] MAKERERE UNIV,MULOGO HOSP,SCH MED,KAMPALA,UGANDA

[2] AIDS CONTROL PROGRAMME,KAMPALA,UGANDA

来源：

TUBERCLE AND LUNG DISEASE | 1994年 / 75卷 / 01期

关键词：

D O I：

10.1016/0962-8479(94)90099-X

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Setting: The diagnostic utility of serodiagnosis of tuberculosis in HIV-infected persons was studied in Kampala, Uganda. Objective: This stud was undertaken to evaluate the utility of a recently described serologic assay for the diagnosis of tuberculosis in HIV-infected patients. Design: The study was undertaken as a cross-sectional survey of 349 subjects, including human immunodeficiency virus-infected and uninfected patients with tuberculosis and control subjects. Serum from each subject was assayed by enzyme-linked immunosorbent assay (ELISA) for IgG antibody to the 30 000 dalton antigen of Mycobacterium tuberculosis. Results: Test sensitivity dropped from 0.62 in non HIV-infected tuberculous patients to 0.28 in HIV-infected patients. Conclusions: ELISA serodiagnosis of tuberculosis may have a markedly decreased utility in populations where HIV infection is prevalent.

引用

页码：33 / 37

页数：5

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