THE TRANSFORMATIONS OF 4-HETEROARYLAMINOMETHYLENE-5(4H)-OXAZOLONES INTO DEHYDROPEPTIDE DERIVATIVES

被引：8

作者：

ALJAZROZIC, M

SVETE, J

STANOVNIK, B

机构：

[1] Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1995年 / 32卷 / 05期

关键词：

D O I：

10.1002/jhet.5570320533

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

2-Phenyl-4-heteroarylaminomethylene-5(4H)-oxazolones 3, which were prepared from the corresponding N,N-dimethyl-N'-heteroarylformamidines 1 and hippuric acid 2 in acetic anhydride, react with amino acids giving dehydropeptide derivatives 4, 5, and 6 as products. Dehydration of N-protected peptides 7-10, containing glycine at the C-terminal, followed by the reaction with formamidines 1 gave 2-substituted-4-heteroarylaminomethylene-5(4H)-oxazolones 11-14.

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页码：1605 / 1611

页数：7

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