PERIVISCEROKININ (PEA-PVK) - A NOVEL MYOTROPIC NEUROPEPTIDE FROM THE PERISYMPATHETIC ORGANS OF THE AMERICAN COCKROACH

被引：57

作者：

PREDEL, R ^{[1
]}

LINDE, D ^{[1
]}

RAPUS, J ^{[1
]}

VETTERMANN, S ^{[1
]}

PENZLIN, H ^{[1
]}

机构：

[1] INST MOLEK BIOTECHNOL, D-07745 JENA, GERMANY

来源：

PEPTIDES | 1995年 / 16卷 / 01期

关键词：

PERIPLANETA AMERICANA; INSECT; NEUROPEPTIDE; MYOTROPIN; NEUROHEMAL ORGANS; VISCERAL MUSCLE;

D O I：

10.1016/0196-9781(94)00144-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A myotropic neuropeptide was isolated From extracts of 1000 abdominal perisympathetic organs of males of the cockroach, Periplaneta americana. This peptide, termed periviscerokinin, has excitatory actions on the hyperneural muscle of Periplaneta americana. After peptide sequence analysis and mass spectrometry, the structure of this peptide was confirmed by chemical synthesis and bioassay to be Gly-Ala-Ser-Gly-Leu-Ile-Pro-Val-Met-Arg-Asn-NH2. This sequence is different from the other known myotropic peptides in insects. The threshold concentration for stimulatory effects of the synthetic peptide on the isolated hyperneural muscle was about 10(-9) M, suggesting a physiological role as a neurohormone.

引用

页码：61 / 66

页数：6

共 18 条

[1] ABDOMINAL PERISYMPATHETIC NEUROHEMAL ORGANS OF THE COCKROACH PERIPLANETA-AMERICANA - INNERVATION REVEALED BY COBALT CHLORIDE DIFFUSION [J].