NANOMOLAR CONCENTRATIONS OF NITRIC-OXIDE REVERSIBLY INHIBIT SYNAPTOSOMAL RESPIRATION BY COMPETING WITH OXYGEN AT CYTOCHROME-OXIDASE

被引：882

作者：

BROWN, GC

COOPER, CE

机构：

[1] UNIV LONDON UNIV COLL,DEPT BIOCHEM & MOLEC BIOL,LONDON WC1E 6BT,ENGLAND

[2] UNIV LONDON UNIV COLL,SCH MED,DEPT PAEDIAT,LONDON WC1E 6JJ,ENGLAND

来源：

FEBS LETTERS | 1994年 / 356卷 / 2-3期

关键词：

NITRIC OXIDE; CYTOCHROME OXIDASE; SYNAPTOSOME; OXYGEN;

D O I：

10.1016/0014-5793(94)01290-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide (NO) reversibly inhibited oxygen consumption of brain synaptosomes. Inhibition was reversible, occurred at the level of cytochrome oxidase, and was apparently competitive with oxygen, with half-inhibition by 270 nM NO at oxygen concentrations around 145 mu M and by 60 nM NO at around 30 mu M O-2. Isolated cytochrome oxidase was inhibited by similar levels of NO. These levels of NO are within the measured physiological and pathological range for a number of tissues and conditions, suggesting that NO inhibition of cytochrome oxidase and the competion with oxygen may occur in vivo.

引用

页码：295 / 298

页数：4

共 24 条

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