BASIC FIBROBLAST GROWTH-FACTOR MESSENGER-RNA IS EXPRESSED STRONGLY AT THE ACUTE STAGE OF CEREBRAL CONTUSION

被引：10

作者：

IWAMOTO, Y ^{[1
]}

YAMAKI, T ^{[1
]}

MURAKAMI, N ^{[1
]}

SUGAWA, N ^{[1
]}

YOSHINO, E ^{[1
]}

UEDA, S ^{[1
]}

NOSAKA, K ^{[1
]}

NISHINO, H ^{[1
]}

IWASHIMA, A ^{[1
]}

机构：

[1] KYOTO PREFECTURAL UNIV MED,DEPT BIOCHEM,KYOTO 602,JAPAN

来源：

LIFE SCIENCES | 1994年 / 55卷 / 21期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; NORTHERN BLOTTING; FLUID PERCUSSION; CEREBRAL CONTUSION;

D O I：

10.1016/0024-3205(94)00332-7

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Basic fibroblast growth factor (bFGF) has a neurotrophic effect both in vitro and in vivo, and is considered to play an important role in the maintenance of neuronal functions in the normal brain. Neural damage in brain contusion progresses after the primary injury of trauma because of cerebral hemodynamic and metabolic impairment including intracranial hemorrhage and/or brain swelling. Northern blot analysis of bFGF mRNA was performed in rats after cerebral contusion produced by our modified fluid percussion device. Expression of bFGF mRNA increased significantly on the second day after trauma. A possible role of bFGF is functioning to protect the critical neurons from secondary neural damage in cerebral contusion.

引用

页码：1651 / 1656

页数：6

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