INHIBITION OF ETHANOL METABOLISM IN VIVO BY 4-IODO-PYRAZOLE

被引：7

作者：

RYDBERG, US

机构：

[1] Department of Alcohol Research, Karolinska Institutet

来源：

BIOCHEMICAL PHARMACOLOGY | 1969年 / 18卷 / 10期

关键词：

D O I：

10.1016/0006-2952(69)90358-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In experiments in rats, the in vivo effect of 4-iodo-pyrazole on ethanol metabolism was studied. An ethanol dose of 32·6 m-mole/kg was administered. Blood samples were withdrawn at regular intervals, and ethanol analyzed by the Widmark method and by gas chromatography. 4-iodo-pyrazole in doses of 0·05 to 1·25 m-mole/kg inhibited the metabolism of ethanol from 19 to 84 per cent, and the presence of ethanol in blood was prolonged from 4 hr in the controls to 28 hr in the experiment with 1·25 m-mole/kg 4-iodo-pyrazole. 4-iodo-pyrazole is a potent ADH blocker, the ed50 being 0·27 m-mole/kg of the same order of magnitude as for pyrazole in vivo. © 1969.

引用

页码：2425 / &

共 10 条

[1]

Bliss CI, 1937, ANN APPL BIOL, V24, P815, DOI 10.1111/j.1744-7348.1937.tb05058.x

[2] GAS CHROMATOGRAPHIE DETERMINATION OF SOME VOLATILE COMPOUNDS IN URINE [J].