NEW STRATEGY FOR THE CONSTRUCTION OF CARBAPENEMS - TOTAL SYNTHESIS OF 6-EPI PS-5 AND PS-5

被引：7

作者：

KOSKINEN, AMP

GHIACI, M

机构：

[1] Department of Chemistry, University of Surrey Guildford

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 22期

关键词：

D O I：

10.1016/S0040-4039(00)94734-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A strategically novel approach to carbapenems has been developed. The pyrrolidine ring is first constructed, appended with the required side chains, and the β-lactam ring is then annealed. We have demonstrated the utility of the approach to the asymmetric synthesis of antibiotics 6-epi PS-5 and PS-5. © 1990.

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页码：3209 / 3212

页数：4

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