EVALUATION OF THE TOXICOLOGIC AND TERATOGENIC POTENTIALS OF SODIUM FLUORESCEIN IN THE RAT

被引：15

作者：

SALEM, H

LOUX, JJ

SMITH, S

NICHOLS, CW

机构：

[1] COOPER LABS,SIMP DIV,DEPT PHARMACOL,CEDAR KNOLLS,NJ

[2] UNIV PENN,SCH MED,DEPT PHARMACOL,PHILADELPHIA,PA 19104

[3] UNIV PENN,SCH MED,DEPT OPHTHALMOL,PHILADELPHIA,PA 19104

来源：

TOXICOLOGY | 1979年 / 12卷 / 02期

关键词：

D O I：

10.1016/0300-483X(79)90040-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Sodium fluorescein (10%) when injected intravenously (5 ml/kg) in pregnant albino rats crossed the placental barrier and appeared to be distributed throughout the fetus within 15 min. It was detectable in the fetus up to 4 h after injection but not beyond 24 h. A single intravenous administration of sodium fluorescein did not produce embryotoxic or teratogenic effects. oral LD50 studies using sodium phenobarbital on rats which received sodium fluorescein during their fetal development showed no apparent effects of sodium fluorescein on their drug detoxification systems. © 1979.

引用

页码：143 / 150

页数：8

共 9 条

[1] COMPARISON OF TERATOGENIC EFFECTS OF MUSTINE HYDROCHLORIDE IN RATS AND FERRETS - VALUE OF FERRET AS AN EXPERIMENTAL ANIMAL IN TERATOLOGY [J].