INTRODUCTION OF BAPTA INTO INTACT RAT SUBMANDIBULAR ACINI INHIBITS MUCIN SECRETION IN RESPONSE TO CHOLINERGIC AND BETA-ADRENERGIC AGONISTS

被引：10

作者：

MILLS, CL ^{[1
]}

DORMER, RL ^{[1
]}

MCPHERSON, MA ^{[1
]}

机构：

[1] UNIV WALES COLL MED,DEPT MED BIOCHEM,HEATH PK,CARDIFF CF4 4XN,S GLAM,WALES

来源：

FEBS LETTERS | 1991年 / 289卷 / 02期

关键词：

SUBMANDIBULAR; MUCIN SECRETION; BETA-ADRENERGIC; CHOLINERGIC; CALCIUM CHELATOR;

D O I：

10.1016/0014-5793(91)81054-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Incorporation of the calcium chelator BAPTA into isolated, intact rat submandibular acini by hypotonic swelling, resulted in complete inhibition of carbamylcholine, noradrenaline and isoproterenol stimulation of mucin secretion. No effects of intracellular BAPTA on cell viability or beta-adrenergic stimulation of cyclic AMP formation were observed. The data are the first to demonstrate that calcium is necessary for beta-adrenergic stimulation of secretion and suggest that Ca2+ provides a common link in the triggering of exocytosis.

引用

页码：141 / 144

页数：4

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