A CHEMOENZYMATIC SYNTHESIS OF OPTICALLY-ACTIVE DIHYDROPYRIDINES

被引：39

作者：

HOLDGRUN, XK ^{[1
]}

SIH, CJ ^{[1
]}

机构：

[1] UNIV WISCONSIN,SCH PHARM,MADISON,WI 53706

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 29期

关键词：

D O I：

10.1016/0040-4039(91)80807-I

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A biocatalytic asymmetric synthesis of optically-active dihydropyridines has been developed. The method entails the enantiotopically-selective solvolysis of the sterically unhindered ester 13 in n-BuOH/H2O catalyzed by Pseudomonas lipases.

引用

页码：3465 / 3468

页数：4

共 17 条

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