AROMATASE ENZYME-ACTIVITY AND SEX DETERMINATION IN CHICKENS

被引:429
作者
ELBRECHT, A
SMITH, RG
机构
[1] Department of Animal Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, Rahway
关键词
D O I
10.1126/science.1734525
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
During development, the genotype of the zygote determines the nature of the gonad, which then determines the male or female phenotype. The molecular events underlying this process are just beginning to be defined. A single treatment of chicken embryos with an aromatase inhibitor (which blocks the synthesis of estrogen from testosterone) at a stage when their gonads were bipotential caused genetic females to develop a permanent male phenotype. These sex-reversed females developed bilateral testes that were capable of complete spermatogenesis and had the physical appearance and behavior of normal males. This result identifies aromatase as a key developmental switch in the sex determination of chickens.
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收藏
页码:467 / 470
页数:4
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