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FEATURES OF SPLICEOSOME EVOLUTION AND FUNCTION INFERRED FROM AN ANALYSIS OF THE INFORMATION AT HUMAN SPLICE SITES
被引:226
作者
:
STEPHENS, RM
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, FREDERICK CANC RES & DEV CTR, MATH BIOL LAB, POB B, FREDERICK, MD 21702 USA
STEPHENS, RM
SCHNEIDER, TD
论文数:
0
引用数:
0
h-index:
0
机构:
NCI, FREDERICK CANC RES & DEV CTR, MATH BIOL LAB, POB B, FREDERICK, MD 21702 USA
SCHNEIDER, TD
机构
:
[1]
NCI, FREDERICK CANC RES & DEV CTR, MATH BIOL LAB, POB B, FREDERICK, MD 21702 USA
[2]
LINGANORE HIGH SCH, FREDERICK, MD 21701 USA
来源
:
JOURNAL OF MOLECULAR BIOLOGY
|
1992年
/ 228卷
/ 04期
基金
:
美国国家卫生研究院;
关键词
:
SPLICE;
SPLICEOSOME;
INFORMATION THEORY;
EVOLUTION;
HUMAN;
D O I
:
10.1016/0022-2836(92)90320-J
中图分类号
:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号
:
071010 ;
081704 ;
摘要
:
An information analysis of the 5′ (donor) and 3′ (acceptor) sequences spanning the ends of nearly 1800 human introns has provided evidence for structural features of splice sites that bear upon spliceosome evolution and function: (1) 82% of the sequence information (i.e. sequence conservation) at donor junctions and 97% of the sequence information at acceptor junctions is confined to the introns, allowing codon choices throughout exons to be largely unrestricted. The distribution of information at intron-exon junctions is also described in detail and compared with footprints. (2) Acceptor sites are found to possess enough information to be located in the transcribed portion of the human genome, whereas donor sites possess about one bit less than the information needed to locate them independently. This difference suggests that acceptor sites are located first in humans and, having been located, reduce by a factor of two the number of alternative sites available as donors. Direct experimental evidence exists to support this conclusion. (3) The sequences of donor and acceptor splice sites exhibit a striking similarity. This suggests that the two junctions derive from a common ancestor and that during evolution the information of both sites shifted onto the intron. If so, the protein and RNA components that are found in contemporary spliceosomes, and which are responsible for recognizing donor and acceptor sequences, should also be related. This conclusion is supported by the common structures found in different parts of the spliceosome. © 1992.
引用
收藏
页码:1124 / 1136
页数:13
相关论文
共 96 条
[1]
5' CLEAVAGE SITE IN EUKARYOTIC PRE-MESSENGER-RNA SPLICING IS DETERMINED BY THE OVERALL 5' SPLICE REGION, NOT BY THE CONSERVED 5' GU
AEBI, M
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0
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0
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0
AEBI, M
HORNIG, H
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0
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0
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HORNIG, H
WEISSMANN, C
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0
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0
h-index:
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WEISSMANN, C
[J].
CELL,
1987,
50
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: 237
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246
[2]
PRECISION AND ORDERLINESS IN SPLICING
AEBI, M
论文数:
0
引用数:
0
h-index:
0
AEBI, M
WEISSMANN, C
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0
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0
h-index:
0
WEISSMANN, C
[J].
TRENDS IN GENETICS,
1987,
3
(04)
: 102
-
107
[3]
THE NUCLEOTIDE-SEQUENCE OF THE YEAST ARG4 GENE
BEACHAM, IR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
BEACHAM, IR
SCHWEITZER, BW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
SCHWEITZER, BW
WARRICK, HM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
WARRICK, HM
CARBON, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
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SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS - FUNCTIONAL SPECIFICITY AND PSEUDOSITE COMPETITION
BERG, OG
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0
引用数:
0
h-index:
0
BERG, OG
[J].
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,
1988,
6
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SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS .2. THE BINDING-SPECIFICITY OF CYCLIC-AMP RECEPTOR PROTEIN TO RECOGNITION SITES
BERG, OG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1988,
200
(04)
: 709
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723
[6]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS - STATISTICAL-MECHANICAL THEORY AND APPLICATION TO OPERATORS AND PROMOTERS
BERG, OG
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0
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0
h-index:
0
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UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1987,
193
(04)
: 723
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743
[7]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS
BERG, OG
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0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
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0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
TRENDS IN BIOCHEMICAL SCIENCES,
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BLOMBERG, C
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KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
BLOMBERG, C
EHRENBERG, M
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
EHRENBERG, M
KURLAND, CG
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
KURLAND, CG
[J].
QUARTERLY REVIEWS OF BIOPHYSICS,
1980,
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ENERGY CONSIDERATIONS FOR KINETIC PROOFREADING IN BIOSYNTHESIS
BLOMBERG, C
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
BLOMBERG, C
EHRENBERG, M
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
EHRENBERG, M
[J].
JOURNAL OF THEORETICAL BIOLOGY,
1981,
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(04)
: 631
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670
[10]
U2 RNA SHARES A STRUCTURAL DOMAIN WITH U1, U4, AND U5 RNAS
BRANLANT, C
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0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
BRANLANT, C
KROL, A
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
KROL, A
EBEL, JP
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h-index:
0
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CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
EBEL, JP
LAZAR, E
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0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
LAZAR, E
HAENDLER, B
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
HAENDLER, B
JACOB, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
JACOB, M
[J].
EMBO JOURNAL,
1982,
1
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: 1259
-
1265
←
1
2
3
4
5
6
7
8
9
10
→
共 96 条
[1]
5' CLEAVAGE SITE IN EUKARYOTIC PRE-MESSENGER-RNA SPLICING IS DETERMINED BY THE OVERALL 5' SPLICE REGION, NOT BY THE CONSERVED 5' GU
AEBI, M
论文数:
0
引用数:
0
h-index:
0
AEBI, M
HORNIG, H
论文数:
0
引用数:
0
h-index:
0
HORNIG, H
WEISSMANN, C
论文数:
0
引用数:
0
h-index:
0
WEISSMANN, C
[J].
CELL,
1987,
50
(02)
: 237
-
246
[2]
PRECISION AND ORDERLINESS IN SPLICING
AEBI, M
论文数:
0
引用数:
0
h-index:
0
AEBI, M
WEISSMANN, C
论文数:
0
引用数:
0
h-index:
0
WEISSMANN, C
[J].
TRENDS IN GENETICS,
1987,
3
(04)
: 102
-
107
[3]
THE NUCLEOTIDE-SEQUENCE OF THE YEAST ARG4 GENE
BEACHAM, IR
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
BEACHAM, IR
SCHWEITZER, BW
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
SCHWEITZER, BW
WARRICK, HM
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
WARRICK, HM
CARBON, J
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
UNIV CALIF SANTA BARBARA,DEPT BIOL SCI,BIOCHEM & MOLEC BIOL SECT,SANTA BARBARA,CA 93106
CARBON, J
[J].
GENE,
1984,
29
(03)
: 271
-
279
[4]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS - FUNCTIONAL SPECIFICITY AND PSEUDOSITE COMPETITION
BERG, OG
论文数:
0
引用数:
0
h-index:
0
BERG, OG
[J].
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS,
1988,
6
(02)
: 275
-
297
[5]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS .2. THE BINDING-SPECIFICITY OF CYCLIC-AMP RECEPTOR PROTEIN TO RECOGNITION SITES
BERG, OG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1988,
200
(04)
: 709
-
723
[6]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS - STATISTICAL-MECHANICAL THEORY AND APPLICATION TO OPERATORS AND PROMOTERS
BERG, OG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
JOURNAL OF MOLECULAR BIOLOGY,
1987,
193
(04)
: 723
-
743
[7]
SELECTION OF DNA-BINDING SITES BY REGULATORY PROTEINS
BERG, OG
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
BERG, OG
VONHIPPEL, PH
论文数:
0
引用数:
0
h-index:
0
机构:
UNIV OREGON,INST MOLEC BIOL,EUGENE,OR 97403
VONHIPPEL, PH
[J].
TRENDS IN BIOCHEMICAL SCIENCES,
1988,
13
(06)
: 207
-
211
[8]
FREE-ENERGY DISSIPATION CONSTRAINTS ON THE ACCURACY OF ENZYMATIC SELECTIONS
BLOMBERG, C
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
BLOMBERG, C
EHRENBERG, M
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
EHRENBERG, M
KURLAND, CG
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED BIOPHYS,S-10401 STOCKHOLM 60,SWEDEN
KURLAND, CG
[J].
QUARTERLY REVIEWS OF BIOPHYSICS,
1980,
13
(02)
: 231
-
254
[9]
ENERGY CONSIDERATIONS FOR KINETIC PROOFREADING IN BIOSYNTHESIS
BLOMBERG, C
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
BLOMBERG, C
EHRENBERG, M
论文数:
0
引用数:
0
h-index:
0
机构:
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
KAROLINSKA INST,DEPT MED PHYS,S-10401 STOCKHOLM 60,SWEDEN
EHRENBERG, M
[J].
JOURNAL OF THEORETICAL BIOLOGY,
1981,
88
(04)
: 631
-
670
[10]
U2 RNA SHARES A STRUCTURAL DOMAIN WITH U1, U4, AND U5 RNAS
BRANLANT, C
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
BRANLANT, C
KROL, A
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
KROL, A
EBEL, JP
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
EBEL, JP
LAZAR, E
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
LAZAR, E
HAENDLER, B
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
HAENDLER, B
JACOB, M
论文数:
0
引用数:
0
h-index:
0
机构:
CNRS,GENET MOLEC EUCARYOTES LAB,11 RUE HUMANN,F-67085 STRASBOURG,FRANCE
JACOB, M
[J].
EMBO JOURNAL,
1982,
1
(10)
: 1259
-
1265
←
1
2
3
4
5
6
7
8
9
10
→