ON THE DISTRIBUTION OF BACTERIAL MUTANTS - THE EFFECTS OF DIFFERENTIAL FITNESS OF MUTANTS AND NON-MUTANTS

被引：8

作者：

JAEGER, G ^{[1
]}

SARKAR, S ^{[1
]}

机构：

[1] DIBNER INST,CAMBRIDGE,MA 02139

来源：

GENETICA | 1995年 / 96卷 / 03期

关键词：

D O I：

10.1007/BF01439575

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

This paper provides an analytic treatment of the effect of differential fitness of mutants and non-mutants on the Luria-Delbruck distribution, which is used to describe the number of mutant cells obtained prior to selection during a fluctuation test experiment. It also systematizes the treatment of the case when the cultures are seeded with multiple cells. One surprising result is that differential fitness of mutants and non-mutants does not affect the mean of the distribution (though, as expected, it decreases the variance). This treatment completes the analysis of the influence of factors that affect the Luria-Delbruck distribution through mechanisms acting prior to plating. All the results that have been obtained to date are collected in a table for easy reference.

引用

页码：217 / 223

页数：7

共 24 条

[1] STATISTICAL CONCEPTS IN THE THEORY OF BACTERIAL MUTATION [J].

ARMITAGE, P .

JOURNAL OF HYGIENE, 1953, 51 (02) :162-184

[2]

ARMITAGE P, 1952, J ROY STAT SOC B, V14, P1

[3]

Bailey N.T.J., 1964, ELEMENTS STOCHASTIC

[4]

Bartlett M. S., 1978, INTRO STOCHASTIC PRO

[5] DIRECTED MUTATION [J].

CAIRNS, J .

SCIENCE, 1993, 260 (5112) :1221-1222

[6] THE ORIGIN OF MUTANTS [J].

CAIRNS, J ;

OVERBAUGH, J ;

MILLER, S .

NATURE, 1988, 335 (6186) :142-145

[7]

DIJKMANS R, 1994, GENETICS, V137, P353

[8]

Feller W, 1970, INTRO PROBABILITY TH, V2

[9] DIRECTED MUTATION - BETWEEN UNICORNS AND GOATS [J].

FOSTER, PL .

JOURNAL OF BACTERIOLOGY, 1992, 174 (06) :1711-1716

[10]

FOSTER PL, 1993, ANNU REV MICROBIOL, V47, P469

← 1 2 3 →