INVIVO CONVERSION OF SODIUM-AZIDE TO A STABLE MUTAGENIC METABOLITE IN SALMONELLA-TYPHIMURIUM

被引：29

作者：

OWAIS, WM ^{[1
]}

KLEINHOFS, A ^{[1
]}

NILAN, RA ^{[1
]}

机构：

[1] WASHINGTON STATE UNIV,DEPT AGRON & SOILS,PULLMAN,WA 99164

来源：

MUTATION RESEARCH | 1979年 / 68卷 / 01期

关键词：

D O I：

10.1016/0165-1218(79)90073-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Salmonella typhimurium TA1530 and G46 strains growing in minimal medium supplemented with sodium azide produce a stable mutagenic metabolite which is not azide. The production of this metabolite is restricted to the log phase of bacteria grown in the presence of azide. The metabolite is highly mutagenic in DNA-repair defective base-substitution strains TA1530 and TA1535, but ineffective in frameshift strains TA1538 and TA1537. The metabolite induces mutations in resting cells of the TA1530 strain. © 1979.

引用

页码：15 / 22

页数：8

共 28 条

[1] IMPROVED BACTERIAL TEST SYSTEM FOR DETECTION AND CLASSIFICATION OF MUTAGENS AND CARCINOGENS
AMES, BN
LEE, FD
DURSTON, WE
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1973, 70 (03) : 782 - 786
[2] METHODS FOR DETECTING CARCINOGENS AND MUTAGENS WITH SALMONELLA-MAMMALIAN-MICROSOME MUTAGENICITY TEST
AMES, BN
MCCANN, J
YAMASAKI, E
[J]. MUTATION RESEARCH, 1975, 31 (06): : 347 - 363
[3] BIRCHFIELD W, 1969, Plant Disease Reporter, V53, P923
[4] THE STIMULATION OF GENE RECOMBINATION IN ESCHERICHIA-COLI
CLARK, JB
HAAS, F
STONE, WS
WYSS, O
[J]. JOURNAL OF BACTERIOLOGY, 1950, 59 (03) : 375 - 379
[5] SODIUM AZIDE-INDUCED MUTANTS OF PEAS THAT ACCUMULATE PISATIN
HADWIGER, LA
SANDER, C
EDDYVEAN, J
RALSTON, J
[J]. PHYTOPATHOLOGY, 1976, 66 (05) : 629 - 630
[6] JONES JW, UNPUBLISHED
[7] EFFECT OF EXCISION REPAIR ON AZIDE-INDUCED MUTAGENESIS
KLEINHOFS, A
SMITH, JA
[J]. MUTATION RESEARCH, 1976, 41 (2-3): : 233 - 239
[8] AZIDE MUTAGENESIS - INVITRO STUDIES
KLEINHOFS, A
KLEINSCHMIDT, M
SCIAKY, D
BROEMBSEN, SV
[J]. MUTATION RESEARCH, 1975, 29 (03): : 497 - 499
[9] KLEINHOFS A, 1974, POLYPLOIDY INDUCED M, P195
[10] KONZAK CF, 1975, MUTAT RES, V30, P55

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