AGE-RELATED MITOCHONDRIAL LIPOPEROXIDATION IN HUMAN-SKIN

被引：8

作者：

SERRI, F ^{[1
]}

BARTOLI, GM ^{[1
]}

SECCIA, A ^{[1
]}

BORRELLO, S ^{[1
]}

GALEOTTI, T ^{[1
]}

机构：

[1] CATHOLIC UNIV ROME, INST GEN PATHOL, I-00168 ROME, ITALY

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 1979年 / 73卷 / 01期

关键词：

D O I：

10.1111/1523-1747.ep12532796

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Mitochondria were isolated from the epidermis of human subjects of different ages by a procedure that included pretreatment of the tissue with bacterial protease before homogenization. That epidermal mitochondria catalyze enzymatic lipid peroxidation in the presence of NADPH and chelated iron (ADP-Fe3+) is indicated by the production of malonaldehyde. The process does not appear to be influenced by age, and it is strongly enhanced in preparations containing a small amount of melanin.

引用

页码：123 / 125

页数：3

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