ALTERNATIVELY SPLICED PLATELET-DERIVED GROWTH-FACTOR A-CHAIN TRANSCRIPTS ARE NOT TUMOR SPECIFIC BUT ENCODE NORMAL CELLULAR PROTEINS

被引：22

作者：

YOUNG, RM

MENDOZA, AE

COLLINS, T

ORKIN, SH

机构：

[1] HARVARD UNIV,CHILDRENS HOSP,SCH MED,DIV HEMATOL ONCOL,BOSTON,MA 02115

[2] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

[3] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

MOLECULAR AND CELLULAR BIOLOGY | 1990年 / 10卷 / 11期

关键词：

D O I：

10.1128/MCB.10.11.6051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two platelet-derived growth factor A-chain proteins, termed short and long A chains, are generated as a result of alternative mRNA splicing of exon 6 of the A-chain gene. S1 nuclease mapping and polymerase chain reaction analyses demonstrate that both short and long A-chain transcripts are expressed in a variety of normal tissues. In addition, immunohistochemical localization of long A-chain protein reveals a cellular distribution identical to that observed with platelet-derived growth factor heteroserum.

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页码：6051 / 6054

页数：4

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