MUTAGENICITY OF FLUORENE DERIVATIVES - PROPOSED MECHANISM

被引：27

作者：

LEVIN, DE ^{[1
]}

BARNES, WS ^{[1
]}

KLEKOWSKI, E ^{[1
]}

机构：

[1] UNIV MASSACHUSETTS,DEPT BOT,AMHERST,MA 01003

来源：

MUTATION RESEARCH | 1979年 / 63卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0027-5107(79)90099-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Several derivatives of fluorene, a tricyclicm organic molecule, have been found to induce both frameshift mutations and base-pair substitutions in Salmonella typhimurium strains developed by Ames. Comparisons of the mutagenic potency of these derivatives for several strains of Salmonella suggest the importance of a carbonyl group substituted at the carbon-9 position of mutagenic derivatives, with respect to mutagenic potency. In this study, we present a feasible mechanism for the interaction of mutagenic fluorene derivatives with deoxyribonucleic acid. This mechanism requires the interaction of the mutagenic molecule with carbon-8 of guanine and a second concurrent interaction with the C-4 amino gropu of an adjacent cytosine residue. © 1979.

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页码：1 / 10

页数：10

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