SYNTHESIS OF 1-ARYL-1,2,3-TRIAZOLE-4,5-DIMETHANOL-4,5-BIS(ISOPROPYLCARBAMATES) AS POTENTIAL ANTINEOPLASTIC AGENTS

被引：26

作者：

LALEZARI, I ^{[1
]}

GOMEZ, LA ^{[1
]}

KHORSHIDI, M ^{[1
]}

机构：

[1] MONTEFIORE MED CTR,ALBERT EINSTEIN COLL MED,DEPT MED,DIV IMMUNOHEMATOL,BRONX,NY 10467

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1990年 / 27卷 / 03期

关键词：

D O I：

10.1002/jhet.5570270338

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Starting with aryl azides, 1‐aryl‐1,2,3‐triazole‐4,5‐dimethanol‐4,5‐bis(isopropylcarbamates), a new class of potential antineoplastic agents, were synthesized. In vitro antileukemic and antitumor actmües of the compounds synthesized were also evaluated. Copyright © 1990 Journal of Heterocyclic Chemistry

引用

页码：687 / 689

页数：3

共 5 条

[1] DESIGN, SYNTHESIS, ANTINEOPLASTIC ACTIVITY, AND CHEMICAL-PROPERTIES OF BIS(CARBAMATE) DERIVATIVES OF 4,5-BIS(HYDROXYMETHYL)IMIDAZOLE
ANDERSON, WK
BHATTACHARJEE, D
HOUSTON, DM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1989, 32 (01) : 119 - 127
[2] BRETSCHNEIDER H, 1950, MONATSH CHEM, V81, P970
[3] SYNTHESIS AND ANTINEOPLASTIC ACTIVITY OF 5-ARYL-2,3-DIHYDROPYRROLO[2,1-B]THIAZOLE-6,7-DIMETHANOL 6,7-BIS(ISOPROPYLCARBAMATES)
LALEZARI, I
SCHWARTZ, EL
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1988, 31 (07) : 1427 - 1429
[4] Michael A., 1898, AM CHEM J, V20, P377
[5] *RECHERCHES SUR LES BENZYL-1-TRIAZOLES-1,2,3 ET PHENYL-1-TRIAZOLES-1,2,3 SUBSTITUES
MOULIN, F
[J]. HELVETICA CHIMICA ACTA, 1952, 35 (01) : 167 - 180

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