VITAMIN DEFICIENCIES AND NEURAL-TUBE DEFECTS - HUMAN AND ANIMAL STUDIES

被引：24

作者：

COCKROFT, DL

机构：

[1] Imperial Cancer Research Fund, Developmental Biology Unit, Department of Zoology, University of Oxford, Oxford OX1 3PS, South Parks Road

来源：

HUMAN REPRODUCTION | 1991年 / 6卷 / 01期

关键词：

DIALYZED SERUM; DIET/NEURAL-TUBE DEFECT; POSTIMPLANTATION EMBRYO CULTURE; VITAMIN DEFICIENCY;

D O I：

10.1093/oxfordjournals.humrep.a137250

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The evidence for an association between vitamin deficiency in early pregnancy and the prevalence of neural-tube defects in humans is reviewed, with particular emphasis on the methodological problems encountered in conducting such studies. It is apparent that there is strong evidence for an association between maternal vitamin status and the outcome of pregnancy, but this is not universally accepted, due to ethical and practical constraints on the design of the studies. There are also problems in obtaining precise information from experiments on animals in vivo. By culturing rat embryos in dialysed serum in which the micromolecular component is defined, it has been possible to demonstrate that significant numbers of neural-tube defects can be produced by the deficiency of a single vitamin (inositol), and that multiple vitamin deficiency produces a further significant increase in the frequency of such defects.

引用

页码：148 / 157

页数：10

共 60 条

[1] Bower C., Stanley F.J., Dietary folate as a risk factor for neural-tube defects: Evidence from a case-control study in Western Australia. Med, J. Aust, 150, pp. 613-619, (1989)
[2] Briggs R.M., Vitamin supplementation as a possible factor in the incidence of cleft lip/palate deformities in humans. Clin. Plast, Surg.T, 3, pp. 647-652, (1976)
[3] Cheng D.W., Chang L.F., Baimson T.A., Gross observations on developing abnormal embryos induced by maternal vitamin, E Deficiency. Anat. Rec, 129, pp. 167-185, (1957)
[4] Cockroft D.L., Nutrient requirements of rat embryos undergoing organogenesis in vitro, J. Reprod. Fertil, 57, pp. 505-510, (1979)
[5] Cockroft D.L., Changes with gestational age in the nutritional requirements of postimplantation rat embryos in culture, Teratology, 38, pp. 281-290, (1988)
[6] Cockroft D.L., Dissection and culture of postimplantation embryos, Postimplantation Mammalian Embryos: A Practical Approach, pp. 15-40, (1990)
[7] Cockroft D.L., Culture media for postimplantation embryos, Reprod. Toxicol, (1991)
[8] Conway H., Effects of supplemental vitamin therapy on the limitation of incidence of cleft tip and cleft palate in humans, Plast. Reconstr. Surg., 22, pp. 450-453, (1958)
[9] Copp A.J., Brook Estibeiro Shum F.A.J.P.A., Cockroft D.L., The embryonic development of mammalian neural tube defects. Prog, Neurobiol, 35, pp. 363-403, (1990)
[10] Creasy M.R., Albcrman E.D., Congenital malformations of the central nervous system in spontaneous abortions, J. Med. Genet, 13, pp. 9-16, (1976)

← 1 2 3 4 5 6 →