EFFECTS OF A NEW CHOLECYSTOKININ ANTAGONIST (GE 410) ON THE SMOOTH-MUSCLE OF THE GUINEA-PIG ILEUM

被引：6

作者：

RAKOVSKA, A ^{[1
]}

MILENOV, K ^{[1
]}

HENKLEIN, P ^{[1
]}

机构：

[1] HUMBOLDT UNIV, INST PHARMACOL & TOXICOL, O-1040 BERLIN, GERMANY

来源：

EXPERIENTIA | 1990年 / 46卷 / 10期

关键词：

[!sup]3[!/sup]H]ACh release; cholecystokinin antagonist (GE 410); Cholecystokinin octapeptide; ileac smooth muscle;

D O I：

10.1007/BF01940666

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Suc-Tyr-(SE)-Met-Gly-Trp-Met-Asp-β-phenethylamide (GE 410) competitively antagonized the contractions of smooth muscle strips from guinea pig ileum (pA2=7.6, n=0.95) induced by cholecystokinin-octapeptide (CCK8). GE 410 inhibited the electrically-induced cholinergically mediated contractile responses and the [3H]ACh release in the ileum, as well as the CCK-stimulated electrical contractile responses and the [3H]ACh release in the cholinergic nerve terminals. The results suggest the existence of CCK-receptors not only in the smooth muscles but also on the neurons. © 1990 Birkhäuser Verlag Basel.

引用

页码：1037 / 1041

页数：5

共 23 条

[1]

ARIENS E, 1985, JAP J PHARM, V25, P1

[2] PHARMACOLOGICAL CHARACTERIZATION OF EXCITATORY AND INHIBITORY CHOLECYSTOKININ RECEPTORS OF THE CAT GALLBLADDER AND SPHINCTER OF ODDI [J].

BEHAR, J ;

BIANCANI, P .

GASTROENTEROLOGY, 1987, 92 (03) :764-770

[3] DIBUTYRYL CYCLIC-GMP, A COMPETITIVE INHIBITOR OF CHOLECYSTOKININ-PANCREOZYMIN AND RELATED PEPTIDES IN THE GALLBLADDER AND ILEUM [J].

DAVISON, JS ;

NAJAFIFARASHAH, A .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1981, 59 (10) :1100-1104

[4]

DAVISON JS, 1982, MOTILITY DIGESTIVE T

[5]

DOCKRAY GJ, 1980, J PHYSIOL-LONDON, V300, pP28

[6] THE SIGNIFICANCE OF PHYSIOLOGICAL [CA2+] AND [MG2+] FOR INVITRO EXPERIMENTS ON SYNAPTIC TRANSMISSION [J].

FOLDES, FF .

LIFE SCIENCES, 1981, 28 (14) :1585-1590

[7] EFFECT OF C-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ ON GUINEA PIG ILEUM AND GALL-BLADDER IN-VITRO [J].

HEDNER, P .

ACTA PHYSIOLOGICA SCANDINAVICA, 1970, 78 (02) :232-&

[8]

MILENOV K, 1988, METHOD FIND EXP CLIN, V10, P741

[9]

RAKOVSKA A, 1987, METHOD FIND EXP CLIN, V9, P429

[10]

RAKOVSKA A, 1988, Drugs of the Future, V13, P34

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