NEW MONOCLONAL-ANTIBODIES REACTING WITH BILE-DUCTS - FURTHER INSIGHTS INTO THE PATHOGENESIS OF BILE DUCTULAR PROLIFERATION IN BILIARY DISEASES

被引：12

作者：

AYRES, RCS ^{[1
]}

HUBSCHER, SG ^{[1
]}

SHAW, J ^{[1
]}

GARNER, C ^{[1
]}

JOPLIN, R ^{[1
]}

WILLIAMS, A ^{[1
]}

NEUBERGER, JM ^{[1
]}

机构：

[1] UNIV BIRMINGHAM,SCH MED,DEPT PATHOL,BIRMINGHAM B15 2TT,W MIDLANDS,ENGLAND

来源：

JOURNAL OF PATHOLOGY | 1991年 / 165卷 / 02期

基金：

英国惠康基金;

关键词：

MONOCLONAL ANTIBODIES; BILIARY EPITHELIAL CELLS;

D O I：

10.1002/path.1711650211

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We have produced a range of monoclonal antibodies which stain human intrahepatic bile ducts of different sizes. Amongst 26 monoclonal antibodies produced, five clones reacted specifically with bile ducts of different sizes, of which three have been maintained in culture and their viability following freezing and thawing confirmed. Staining patterns varied between normal adult liver tissue, normal fetal liver tissue and a variety of hepatobiliary diseases. The antibodies provide further evidence of the immunological heterogeneity of the human intrahepatic biliary tree and support the hypothesis that proliferating bile ductules are derived from periseptal hepatocytes. The preparation of the antibodies, their staining reactions in normal adult, normal fetal and a variety of liver diseases are described.

引用

页码：153 / 161

页数：9

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