PHILADELPHIA POSITIVE ACUTE-LEUKEMIA WITH MINOR BREAKPOINT CLUSTER REARRANGEMENT MAY BE A STEM-CELL DISEASE

被引:11
作者
JACKSON, GH
MIDDLETON, P
PRINCE, R
BOWN, N
KERNAHAN, J
REID, MM
机构
[1] ROYAL VICTORIA INFIRM,DEPT CHILD HLTH,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[2] UNIV NEWCASTLE UPON TYNE,DEPT MED,LEUKAEMIA RES FUND,REMISS UNIT,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
[3] UNIV NEWCASTLE UPON TYNE,DEPT HUMAN GENET,NEWCASTLE TYNE NE1 7RU,TYNE & WEAR,ENGLAND
关键词
D O I
10.1111/j.1365-2141.1992.tb08175.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The biology of Philadelphia chromosome positive (Ph+) acute lymphoblastic leukaemia (ALL) is the subject of much interest. We present a case of Ph+ ALL with a minor breakpoint cluster (mBCR) rearrangement who subsequently relapsed with Ph+ mBCR+ acute myeloid leukaemia and later with Ph+ mBCR+ acute stem cell leukaemia. This case provides further evidence that Ph+ ALL with a mBCR rearrangement may arise from a pluripotent stem cell with similar potential to that of chronic granulocytic leukaemia to undergo blastic crises with differing lineage characteristics.
引用
收藏
页码:77 / 80
页数:4
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