EXPERIMENTAL SIMVASTATIN-INDUCED MYOPATHY IN RABBITS

被引：39

作者：

NAKAHARA, K

KURIYAMA, M

YOSHIDOME, H

NAGATA, K

NAGADO, T

NAKAGAWA, M

ARIMURA, K

HIGUCHI, I

OSAME, M

机构：

[1] Third Department of Internal Medicine, Kagoshima University School of Medicine, Kagoshima

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1992年 / 113卷 / 01期

关键词：

HMG-COA REDUCTASE INHIBITOR; SIMVASTATIN; RHABDOMYOLYSIS; ACUTE INTOXICATION; MYOTONIC DISCHARGE; ANIMAL MODEL; MYOGLOBINURIA; SARCOLEMMA;

D O I：

10.1016/0022-510X(92)90273-N

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We induced experimental myopathy in rabbits by giving simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor. After oral administration of simvastatin (50 mg/kg/day) for 2 weeks, serum CK was elevated in 5 of 7 rabbits; degenerating or necrotic fibers were seen in 3 rabbits. Using electromyography, myotonic discharges were found in the 2 rabbits examined. The combination of myotonic discharges, necrosis and raised serum CK levels suggests that the myopathy was induced by lesions of the muscle surface membrane.

引用

页码：114 / 117

页数：4

共 21 条

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