SOLUTION OF THE RIBOSOME RIDDLE - HOW THE RIBOSOME SELECTS THE CORRECT AMINOACYL-TRANSFER RNA OUT OF 41 SIMILAR CONTESTANTS

被引:46
作者
NIERHAUS, KH
机构
[1] Max-Planck-Institut für Molekulare Genetik, Berlin, D-14195
关键词
D O I
10.1111/j.1365-2958.1993.tb01726.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Three tRNA binding sites, the A, P and E sites, have been demonstrated on ribosomes of bacterial, archaebacterial and eukaryotic origin. In all these cases the first and the third site, the A and the E site, are allosterically coupled in the sense of a negative co-operativity. Therefore, the allosteric three-site model seems to be a generally valid description of the ribosomal elongation phase, where in a cycle of reactions the nascent peptide chain is prolonged by one amino acid. The molecular concept of the allosteric three-site model explains the astonishing ability of the ribosome to select the correct substrate out of a large number of very similar substrates, and it provides a framework within which the mechanisms of the elongation factors could be understood.
引用
收藏
页码:661 / 669
页数:9
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