DRUG-INTERACTIONS WITH ZIDOVUDINE PHOSPHORYLATION IN-VITRO

被引：38

作者：

HOGGARD, PG ^{[1
]}

VEAL, GJ ^{[1
]}

WILD, MJ ^{[1
]}

BARRY, MG ^{[1
]}

BACK, DJ ^{[1
]}

机构：

[1] UNIV LIVERPOOL,DEPT PHARMACOL & THERAPEUT,LIVERPOOL L69 3BX,MERSEYSIDE,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1995年 / 39卷 / 06期

关键词：

D O I：

10.1128/AAC.39.6.1376

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have investigated the effect of a range of drugs (some commonly coadministered with zidovudine [ZDV] to human immunodeficiency virus-positive patients) on intracellular phosphorylation of ZDV by stimulated peripheral blood mononuclear cells, Molt 4 cells, and U937 cells in vitro. Of the drugs tested (azoles, antiviral agents, antibiotics, and anticancer agents), only doxorubicin and ribavirin caused inhibition of anabolite formation as measured by high-performance liquid chromatography. This in vitro approach may provide important leads to potential interactions at the phosphorylation level in patients with human immunodeficiency virus disease. It is reassuring that so many commonly administered drugs do not alter ZDV phosphorylation.

引用

页码：1376 / 1378

页数：3