MOLECULAR CHIRAL RECOGNITION IN SUPERCRITICAL SOLVENTS

被引：34

作者：

FOGASSY, E ^{[1
]}

ACS, M ^{[1
]}

SZILI, T ^{[1
]}

SIMANDI, B ^{[1
]}

SAWINSKY, J ^{[1
]}

机构：

[1] TECH UNIV BUDAPEST,DEPT CHEM IND PROC,H-1521 BUDAPEST,HUNGARY

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 02期

关键词：

D O I：

10.1016/S0040-4039(00)76525-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The intensity of molecular chiral interactions resulting in differences between physical and chemical properties of diastereomeric molecules is solvent dependent. This difference makes it possible to separate the enantiomers of a given substance by using chiral agents. A solvent of supercritical state was involved to study its influence on molecular chiral recognition. It was observed that the differences between the diastereomers in supercritical CO2 are so big compared to traditional solvents that a novel, more efficient method for optical resolution can be developed, employing a variety of resolution agents in a much wider range than it was previously assumed.

引用

页码：257 / 260

页数：4

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