A STUDY OF ELECTROPHILIC SUBSTITUTION IN PYRROLO[2,3-D]PYRIMIDINE RING

被引：27

作者：

GERSTER, JF

HINSHAW, BC

ROBINS, RK

TOWNSEND, LB

机构：

[1] Department of Chemistry, University of Utah, Salt Lake, Utah

[2] 3M Company, St. Paul, Minnesota

[3] Department of Chemistry, University of Utah, Salt Lake, Utah

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1969年 / 6卷 / 02期

关键词：

D O I：

10.1002/jhet.5570060211

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Several 4,5‐disubstituted pyrrolo[2,3‐d ]pyrimidines were prepared for the first time via electrophilic substitution, e.g. halogenation, nitration and sulfonation. PMR data for certain pyrrolo[2,3‐d]pyrimidines are included which has furnished conclusive evidence that electrophilic substitution occurred at position 5. These pyrrolo[2,3‐d]pyrimidines, with electron ‐withdrawing substituents at position 5, are of considerable interest as bases for the preparation of nucleoside derivatives related to tubercidin, toyocamcin and sangivamycin. Copyright © 1969 Journal of Heterocyclic Chemistry

引用

页码：207 / &

共 19 条

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