ANALGETICS .2. RELATIONSHIP BETWEEN STRUCTURE AND ACTIVITY OF SOME BETA-AMINO KETONES

A number of substituted 1,2,5,4-tetrahydro-4-quiuolinols and related compounds were prepared and found devoid of analgetic activity. The successful synthesis of a series of β-aminopropiophenones, considered to be open-chain analogs of active 2,3-dihydro-4-qiunolones, yielded compounds more potent than their closed-ring analogs. © 1969, American Chemical Society. All rights reserved.