INFLUENCE OF GENETIC VARIABLES ON MEANS, VARIANCES, AND COVARIANCES IN BEHAVIORAL-RESPONSES TO TOXICOLOGICAL AND PHARMACOLOGICAL SUBSTANCES

被引：13

作者：

MCCLEARN, GE ^{[1
]}

机构：

[1] UNIV COLORADO,COUNCIL RES CREAT WORK,BOULDER,CO 80302

来源：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH | 1979年 / 5卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1080/15287397909529733

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Inbred strains and F2 generations provide strong experimental control in toxicological studies by virtue of the relative stability of their means. Their variances do not always conform to simple expectations, with respect either to each other or to segregating populations. For the evaluation of covariances or correlations, populations of choice are genetically segregating ones. A genetic approach of demonstrated power but as yet limited application to toxicological problems is that of selective breeding, a procedure by which lines of animals can be developed to precise specifications. © 1977 by Hemisphere Publishing Corporation.

引用

页码：145 / 156

页数：12

共 8 条

[1]

BROADHURST PL, 1977, HDB PSYCHOPHARMACOLO, V7, P265

[2]

BRUELL JH, 1962, ROOTS BEHAVIOR, P48

[3]

MCCLEARN G. E., 1970, Contributions to behavior-genetic analysis., P3

[4]

McClearn G.E., 1968, NEBRASKA S MOTIVATIO, P47

[5]

MCCLEARN GE, 1975, BEHAV GENET, V5, P103

[6] GENETIC FACTORS IN ALCOHOL PREFERENCE OF LABORATORY MICE [J].

MCCLEARN, GE ;

RODGERS, DA .

JOURNAL OF COMPARATIVE AND PHYSIOLOGICAL PSYCHOLOGY, 1961, 54 (02) :116-&

[7]

MCCLEARN GE, 1964, GENETICS TODAY, V3, P795

[8]

MCCLEARN GE, 1962, 3RD P INT C ALC ROAD, P153

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