IDENTIFICATION AND CHARACTERIZATION OF A HEPATIC-MICROSOMAL GLUCOSE-TRANSPORT PROTEIN - T-3 OF THE GLUCOSE-6-PHOSPHATASE SYSTEM

被引：47

作者：

WADDELL, ID

SCOTT, H

GRANT, A

BURCHELL, A

机构：

[1] UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT OBSTET & GYNECOL, CTR RES HUMAN DEV, DUNDEE DD1 9SY, SCOTLAND

[2] UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT CHILD HLTH, DUNDEE DD1 9SY, SCOTLAND

来源：

BIOCHEMICAL JOURNAL | 1991年 / 275卷

关键词：

D O I：

10.1042/bj2750363

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A 52kDa polypeptide in rat liver microsomes was identified as a glucose-binding protein by its ability to weakly bind cytochalasin B and by its cross-reactivity to an antibody raised against the human erythrocyte glucose transport protein. The microsomal glucose binding polypeptide was purified by affinity chromatography and an antibody was raised against it. The inhibitory effect of this antibody on rat microsomal glucose-6-phosphatase activity and on glucose transport out of microsomal vesicles indicates that this protein is a microsomal glucose transport protein.

引用

页码：363 / 367

页数：5

共 41 条

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