ATTENUATION OF EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS BY COMPOUND 48-80 IN LEWIS RATS

被引：25

作者：

STANLEY, NC ^{[1
]}

JACKSON, FL ^{[1
]}

ORR, EL ^{[1
]}

机构：

[1] TEXAS COLL OSTEOPATH MED,DEPT ANAT & CELL BIOL,3500 CAMP BOWIE BLVD,FT WORTH,TX 76107

来源：

JOURNAL OF NEUROIMMUNOLOGY | 1990年 / 29卷 / 1-3期

关键词：

Compound; 48/80; Experimental autoimmune encephalomyelitis; Lewis rat; Mast cell;

D O I：

10.1016/0165-5728(90)90165-J

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The appearance of increased levels of histamine in the central nervous system (CNS) concomitant with the development of clinically significant acute experimental autoimmune encephalomyelitis (EAE) in male Lewis rats suggests that CNS-associated mast cells may mediate acute EAE in Lewis rats. We now report that, compared to controls, rats with acute EAE exhibit fewer detectable mast cells in their dura mater and velum interpositum. In addition, intracisternal, but not intraperitoneal administration of Compound 48/80 just prior to the appearance of clinical signs of acute or recurrent EAE in male and female rats, respectively, significantly attenuates the clinical severity of both forms of EAE. These results further support the hypothesis that CNS-associated, but not peripheral mast cells are mediators or modulators of acute and recurrent EAE in Lewis rats. © 1990.

引用

页码：223 / 228

页数：6

共 17 条

[1] EFFECT OF HYPOTHALAMIC-LESIONS ON EXPERIMENTAL AUTOIMMUNE-DISEASES IN RATS [J].

ABRAMSKY, O ;

WERTMAN, E ;

RECHES, A ;

BRENNER, T ;

OVADIA, H .

ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 496 :360-365

[2]

Arnason B G, 1983, Neurol Clin, V1, P765

[3]

ARNASON BG, 1985, AUTOIMMUNE DISEASES, P399

[4]

DIETSCH GN, 1989, J IMMUNOL, V142, P1476

[5]

DROPP JJ, 1976, ACTA ANAT, V94, P1

[6]

HINRICHS P, 1987, IMMUNE REGULATION CH, P641

[7] THE EFFECTS OF INTRACEREBROVENTRICULAR ADMINISTRATION OF COMPOUND 48/80 ON BEHAVIOR AND REGIONAL BRAIN AMINE CONCENTRATIONS IN THE RAT [J].

LEWIS, SJ ;

QUINN, MJ ;

FENNESSY, MR ;

JARROTT, B .

NEUROSCIENCE LETTERS, 1986, 65 (01) :84-88

[8]

LOVENBERG TW, 1988, J PHARMACOL EXP THER, V247, P562

[9]

LUBLIN FD, 1985, SPRINGER SEMINARS IM, P1

[10] DURAL MAST-CELLS - SOURCE OF CONTAMINATING HISTAMINE IN ANALYSES OF MOUSE-BRAIN HISTAMINE LEVELS [J].

ORR, EL .

JOURNAL OF NEUROCHEMISTRY, 1984, 43 (05) :1497-1499

← 1 2 →