CLUSTERS OF CJD IN SLOVAKIA - THE 1ST STATISTICALLY SIGNIFICANT TEMPOROSPATIAL ACCUMULATIONS OF RURAL CASES

被引：19

作者：

MITROVA, E

BRONIS, M

机构：

[1] Institute of Preventive and Clinical Medicine, Bratislava

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1991年 / 7卷 / 05期

关键词：

CJD; TEMPOROSPATIAL CLUSTERING; STATISTICAL SIGNIFICANCE; CAUSAL RELATIONSHIP;

D O I：

10.1007/BF00143120

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

A space-time analysis of clustering among 78 definite CJD cases who died in Slovakia (75) and an adjacent part of Hungary (3) during 1972-1991 is presented. Two geographical rural accumulations of sporadic and familial CJD patients in the north and south of Central Slovakia were found. There was evidence of two significant clusters when spatial and temporal neighborhoods were defined by distances of 2, 4, 5 and 7 km within 1.5 and 2 years. Involvement of genetic mechanisms in the clusters was demonstrated, and the possible role of environmental (zoonotic) risk factors are considered.

引用

页码：450 / 456

页数：7

共 17 条

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