PROLONGATION OF MAGNETIC-RESONANCE T(2) TIME IN HIPPOCAMPUS OF HUMAN PATIENTS MARKS THE PRESENCE AND SEVERITY OF ALZHEIMERS-DISEASE

被引:53
作者
KIRSCH, SJ
JACOBS, RW
BUTCHER, LL
BEATTY, J
机构
[1] UNIV CALIF LOS ANGELES,COGNIT SCI RES PROGRAM,LOS ANGELES,CA 90024
[2] UNIV CALIF LOS ANGELES,SCH MED,DEPT PSYCHIAT,LOS ANGELES,CA 90024
[3] VALLEY HOSP MED CTR,MENTAL HLTH ADM,VAN NUYS,CA 91405
关键词
ALZHEIMERS DISEASE; MAGNETIC RESONANCE IMAGING; SPIN-SPIN RELAXATION TIME; HIPPOCAMPUS;
D O I
10.1016/0304-3940(92)90513-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Spin-spin relaxation time (T2) was measured in the hippocampal formation, thalamus, and cortical white matter in 13 patients with probable Alzheimer's disease (AD), 11 elderly normal individuals, 23 young persons, and 9 subjects diagnosed with multi-infarct dementia. LAMBDA 0.04 tesla magnetic resonance scanner was used. Hippocampal T2 values for all AD patients exceeded those of any non-AD individual, regardless of age or dementia due to infarction. Further, these T2 values were highly correlated (+ 0.96) with the severity of functional and cognitive impairment of the AD patients. This T2 prolongation was not observed at the other sites examined. These results suggest that hippocampal T2 prolongation may provide a specific marker by which AD pathology can be detected, characterized, and followed in vivo.
引用
收藏
页码:187 / 190
页数:4
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