ANTIMUTAGENIC EFFICACY OF HIGHER DOSES OF VITAMIN-C

被引：30

作者：

KHAN, PK ^{[1
]}

SINHA, SP ^{[1
]}

机构：

[1] BHAGALPUR UNIV,DEPT ZOOL,BHAGALPUR 812007,INDIA

来源：

MUTATION RESEARCH | 1993年 / 298卷 / 03期

关键词：

ENDOSULFAN; PHOSPHAMIDON; MANCOZEB; VITAMIN-C; CLASTOGENICITY;

D O I：

10.1016/0165-1218(93)90036-D

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptive changes in the bone marrow cells of young Swiss albino mice. Of the three doses (10, 20 or 40 mg/kg b.wt./day) of the vitamin, the one which is double the human therapeutic dose (20 mg/kg b.wt./day) was most effective as an antimutagen to be followed by 40 mg and 10 mg. None of these doses of vitamin C showed any genotoxicity of their own for the parameters studied here.

引用

页码：157 / 161

页数：5

共 30 条

[1] AFLATOXIN-INDUCED STRUCTURAL CHROMOSOMAL CHANGES AND MITOTIC DISRUPTION IN MOUSE BONE-MARROW [J].