IDENTIFICATION OF TRYPTOPHAN 2,3-DIOXYGENASE RNA IN RODENT BRAIN

被引:71
作者
HABER, R
BESSETTE, D
HULIHANGIBLIN, B
DURCAN, MJ
GOLDMAN, D
机构
[1] Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland
关键词
TRYPTOPHAN 2,3-DIOXYGENASE; RODENT BRAIN; RNA AMPLIFICATION;
D O I
10.1111/j.1471-4159.1993.tb03269.x
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The gene for tryptophan 2,3-dioxygenase (TDO) heretofore was believed to be expressed only in liver. The data presented here demonstrate that RNA encoding TDO is present in rodent brain. Oligonucleotide primers based on the rat liver TDO cDNA sequence were synthesized and used to amplify RNA derived from mouse whole brain and liver and rat brain regions by the RNA-PCR. Reaction products were purified and subjected to DNA sequencing. Identical sequences were obtained when mouse whole brain and liver RNAs were amplified, and these sequences were shown to be 96% identical to the published rat liver tryptophan TDO cDNA sequence. In addition, TDO sequences were found in RNA derived from rat brainstem, cerebellum, cortex, hypothalamus and the remainder of the brain.
引用
收藏
页码:1159 / 1162
页数:4
相关论文
共 18 条
[1]  
DAI W, 1990, J BIOL CHEM, V265, P19871
[2]   GLUCOCORTICOID INDUCTION OF THE RAT TRYPTOPHAN OXYGENASE GENE IS MEDIATED BY 2 WIDELY SEPARATED GLUCOCORTICOID-RESPONSIVE ELEMENTS [J].
DANESCH, U ;
GLOSS, B ;
SCHMID, W ;
SCHUTZ, G ;
SCHULE, R ;
RENKAWITZ, R .
EMBO JOURNAL, 1987, 6 (03) :625-630
[3]   CEREBRAL TRYPTOPHAN-2,3-DIOXYGENASE (PYRROLASE) AND ITS INDUCTION IN RAT-BRAIN [J].
GAL, EM .
JOURNAL OF NEUROCHEMISTRY, 1974, 22 (05) :861-862
[4]   THE ADAPTIVE INCREASE OF THE TRYPTOPHAN PEROXIDASE-OXIDASE SYSTEM OF LIVER [J].
KNOX, WE ;
MEHLER, AH .
SCIENCE, 1951, 113 (2931) :237-238
[5]  
KNOX WE, 1955, J BIOL CHEM, V214, P301
[6]  
Lapin IP, 1989, QUINOLINIC ACID KYNU, P193
[7]   DEDUCED PRIMARY STRUCTURE OF RAT TRYPTOPHAN-2,3-DIOXYGENASE [J].
MAEZONO, K ;
TASHIRO, K ;
NAKAMURA, T .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1990, 170 (01) :176-181
[8]  
NAKAMURA T, 1980, J BIOL CHEM, V255, P7533
[9]   INTERFERON-GAMMA BLOCKS THE GROWTH OF TOXOPLASMA-GONDII IN HUMAN-FIBROBLASTS BY INDUCING THE HOST-CELLS TO DEGRADE TRYPTOPHAN [J].
PFEFFERKORN, ER .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1984, 81 (03) :908-912
[10]   ISOLATION AND CHARACTERIZATION OF THE RAT TRYPTOPHAN OXYGENASE GENE [J].
SCHMID, W ;
SCHERER, G ;
DANESCH, U ;
ZENTGRAF, H ;
MATTHIAS, P ;
STRANGE, CM ;
ROWEKAMP, W ;
SCHUTZ, G .
EMBO JOURNAL, 1982, 1 (10) :1287-1293