IGM HEXAMERS

被引：43

作者：

BREWER, JW

RANDALL, TD

PARKHOUSE, RME

CORLEY, RB

机构：

[1] STANFORD UNIV,MED CTR,SCH MED,DEPT PATHOL,STANFORD,CA 94305

[2] PIRBRIGHT LAB,INST ANIM HLTH,DIV IMMUNOL,PIRBRIGHT GU24 LNF,SURREY,ENGLAND

来源：

IMMUNOLOGY TODAY | 1994年 / 15卷 / 04期

关键词：

D O I：

10.1016/0167-5699(94)90313-1

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

There has been a universal tendency to regard IgM antibodies as pentameric molecules comprising five immunoglobulin monomeric subunits joined by a single J-chain protein. Is this the only form of secreted IgM, or are the possibilities more complex? In this article, Joseph Brewer and colleagues propose that the IgM polymers secreted in primary immune responses may be more heterogeneous than previously believed and that, as a consequence, the biological activity of IgM may have considerable flexibility.

引用

收藏

页码：165 / 168

页数：4

相关论文

共 26 条

[1] SPLENIC DEPENDENCE OF THE ANTIBODY-RESPONSE TO THYMUS-INDEPENDENT (TI-2) ANTIGENS [J].

AMLOT, PL ;

GRENNAN, D ;

HUMPHREY, JH .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1985, 15 (05) :508-512

[2] DIRECT EVIDENCE FOR AN INTEGRATED FUNCTION OF J-CHAIN AND SECRETORY COMPONENT IN EPITHELIAL TRANSPORT OF IMMUNOGLOBULINS [J].

BRANDTZAEG, P ;

PRYDZ, H .

NATURE, 1984, 311 (5981) :71-74

[3]

BREWER JW, IN PRESS J BIOL CHEM

[4] POLYMERIC IMMUNOGLOBULIN-M IS SECRETED BY TRANSFECTANTS OF NONLYMPHOID CELLS IN THE ABSENCE OF IMMUNOGLOBULIN-J CHAIN [J].

CATTANEO, A ;

NEUBERGER, MS .

EMBO JOURNAL, 1987, 6 (09) :2753-2758

[5] IGM - MOLECULAR REQUIREMENTS FOR ITS ASSEMBLY AND FUNCTION [J].

DAVIS, AC ;

SHULMAN, MJ .

IMMUNOLOGY TODAY, 1989, 10 (04) :118-+

[6] ON THE STRUCTURE OF POLYMERIC IGM [J].

DAVIS, AC ;

ROUX, KH ;

SHULMAN, MJ .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (07) :1001-1008

[7] INTERMOLECULAR DISULFIDE BONDING IN IGM - EFFECTS OF REPLACING CYSTEINE RESIDUES IN THE MU-HEAVY CHAIN [J].

DAVIS, AC ;

ROUX, KH ;

PURSEY, J ;

SHULMAN, MJ .

EMBO JOURNAL, 1989, 8 (09) :2519-2526

[8] IGM REASSOCIATION INVITRO - NO INFLUENCE OF J-CHAIN ON AMOUNT OF POLYMERS [J].

ESKELAND, T .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1974, 3 (06) :757-768

[9] DOES J-CHAIN MEDIATE COMBINATION OF 19S-IGM AND DIMERIC IGA WITH SECRETORY COMPONENT RATHER THAN BEING NECESSARY FOR THEIR POLYMERIZATION [J].

ESKELAND, T ;

BRANDTZAEG, P .

IMMUNOCHEMISTRY, 1974, 11 (03) :161-163

[10] IGM MOLECULES WITH AND WITHOUT J-CHAIN IN SERUM AND AFTER PURIFICATION, STUDIED BY ULTRACENTRIFUGATION, ELECTROPHORESIS, AND ELECTRON-MICROSCOPY [J].

ESKELAND, T ;

CHRISTENSEN, TB .

SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 1975, 4 (03) :217-228