SPECIES-SPECIFICITY OF TRANSCRIPTION BY RNA-POLYMERASE-I

被引：52

作者：

HEIX, J

GRUMMT, I

机构：

[1] Division of Molecular Biology of the Cell II, German Cancer Research Center, D-69120 Heidelberg

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1995年 / 5卷 / 05期

关键词：

D O I：

10.1016/0959-437X(95)80035-2

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An unusual property of ribosomal gene transcription is its marked species specificity. This results from distinct promoter-recognition properties of the RNA polymerase I transcription apparatus. The purification and functional characterization of TIF-IB/SL1, a promoter-recognition factor containing the TATA-binding protein, as well as the recent cloning of cDNAs encoding the three subunits (TAF(l)s) of the respective human and mouse factor, wi II facillitate the molecular analysis of the mechanisms underlying species-specific rDNA transcription and reveal how the basal transcriptional machinery has evolved.

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页码：652 / 656

页数：5

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