OSMOTIC SENSITIVITY OF THE HYPERPOLARIZATION-ACTIVATED CL- CURRENT IN MOUSE MANDIBULAR DUCT CELLS

被引：16

作者：

KOMWATANA, P ^{[1
]}

DINUDOM, A ^{[1
]}

YOUNG, JA ^{[1
]}

COOK, DI ^{[1
]}

机构：

[1] UNIV SYDNEY,DEPT PHYSIOL F13,SYDNEY,NSW 2006,AUSTRALIA

来源：

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 1995年 / 5卷 / 04期

关键词：

CL-; CONDUCTANCE; CLC-2; CHANNEL; DIDS; DPC; OSMOLALITY; GRANULAR DUCTS; MOUSE MANDIBULAR GLANDS;

D O I：

10.1159/000154759

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have previously shown that unstimulated mouse mandibular granular duct cells contain a hyperpolarization-activated Cl- conductance having characteristics similar to those of ClC-2 channels. We now show that exposure of the granular duct cells to hypotonic solutions inhibits the hyperpolarization-activated Cl- current whereas exposure to hypertonic solutions causes it to be transiently activated and then inhibited. Like ClC-2 channels in Xenopus oocytes, the hyperpolarization-activated Cl- current in mouse granular duct cells is sensitive to osmolality, although its response to osmolality is the reverse of that seen with ClC-2 channels, perhaps due to a difference in the mechanism by which the osmolality signal is transduced to a change in channel activity.

引用

页码：243 / 251

页数：9

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