CHROMOSOMAL MUTANTS OF SACCHAROMYCES-CEREVISIAE AFFECTING CELL-WALL BINDING-SITE FOR KILLER FACTOR

Fifty-two killer, factor-resistant, nuclear mutants were isolated from sensitive strains of yeast and assorted into 3 functional groups. All but 1 mutant owed their resistance to an alteration in the cell wall binding site for killer. In several mutant strains, an alteration at the site of killer binding was associated with a change in the susceptibility of the cell wall to degradation by glusulase. The killer-binding site was inactivated by periodate but not by pronase treatment. The nature of the site is discussed.