KI-1+ CUTANEOUS LYMPHOMA - GENE REARRANGEMENT ANALYSIS OF TUMOR-CELLS IN TISSUE AND SHORT-TERM CULTURE OF A PATIENT

被引：22

作者：

SUGIMOTO, H

NAKAYAMA, F

YAMAUCHI, T

TOKURA, Y

IWATSUKI, K

TAKIGAWA, M

YAMADA, M

MAEDA, M

机构：

[1] KYOTO UNIV, CHEST DIS RES INST, KYOTO 606, JAPAN

[2] RED CROSS HOSP, DEPT DERMATOL, HAMAMATSU, JAPAN

[3] SHIZUOKA GEN HOSP, DEPT DERMATOL, SHIZUOKA, JAPAN

来源：

ARCHIVES OF DERMATOLOGY | 1988年 / 124卷 / 03期

关键词：

D O I：

10.1001/archderm.124.3.405

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Cutaneous malignant lymphomas developed in an 80-year-old man without any evidence of leukemia disseminations of lymphoma cells. Immunohistologic staining showed the expression of Leu-3a, Leu-4, Ki-1, Tac, and HLA-DR antigens on tumor cells in tissue and large lymphoid cells in long-term, interleukin 2-containing culture of tumor explants. DNA samples extracted from the skin tumors and cultured lymphoid cells showed a clonal rearrangement of T-cell receptor (TCR) gene C.beta., with the molecular size of 9 kilobases. These findings suggested the T-cell origin of Ki-1+ cutaneous lymphoma cells and the occurrence of a clonal proliferation of tumor cells in culture.

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页码：405 / 408

页数：4

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