ADRIAMYCIN - PROPOSAL ON SPECIFICITY OF DRUG ACTION

被引：138

作者：

TRITTON, TR ^{[1
]}

MURPHREE, SA ^{[1
]}

SARTORELLI, AC ^{[1
]}

机构：

[1] YALE UNIV,SCH MED,CTR COMPREHENS CANC,PROGRAM DEV THERAPEUT,NEW HAVEN,CT 06510

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1978年 / 84卷 / 03期

关键词：

D O I：

10.1016/0006-291X(78)90775-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Adriamycin has been found to decrease the gel to liquid crystal transition temperature of liposomal membranes of varying compositions. However, when a low level of cardiolipin was inserted into a lecithin-containing membrane matrix, drug interaction caused the opposite effect on the thermal transition. It is suggested that this phenomenon may be indicative of specificity in the cytotoxic action of adriamycin on tumors, because evidence exists which indicates that certain neoplastic cells may contain cardiolipin in their plasma membrane and thus present a different surface to the drug than a non-malignant cell. © 1978.

引用

页码：802 / 808

页数：7

共 13 条

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