1,2-ADDITION OF DIMETHYL(PHENYL)SILYLLITHIUM TO CYCLIC ALPHA,BETA-UNSATURATED KETONES AND REGIOSPECIFIC GENERATION OF CYCLIC SILYL ENOL ETHERS THROUGH BROOK REARRANGEMENT OF THE 1,2-ADDITION PRODUCTS

被引：30

作者：

KOREEDA, M

KOO, S

机构：

[1] Deparment of Chemistry, The University of Michigan, Ann Arbor

来源：

TETRAHEDRON LETTERS | 1990年 / 31卷 / 06期

关键词：

D O I：

10.1016/S0040-4039(00)94639-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convenient two-step sequence for the regiospecific synthesis of cyclic silyl enol ethers has been developed involving the 1,2-addition of dimethyl(phenyl)silyllithium to cyclic α,β-unsaturated ketones followed by the treatment of the resulting silyl carbinols with a catalytic amount of NaH in THF at 25 °C. © 1990.

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页码：831 / 834

页数：4

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